STUDIES ON THE EFFECT OF A NEW RADIOSENSITIZER CM ON THE DNase ACTIVITY OF IRRADIATED HEPATIC TUMOR CELLS

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STUDIES ON THE EFFECT OF A NEW RADIOSENSITIZER CM ON THE DNase ACTIVITY OF IRRADIATED HEPATIC TUMOR CELLS

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- STUDIES ON THE EFFECT OF A NEW RADIOSENSITIZER CM ON THE DNase ACTIVITY OF IRRADIATED HEPATIC TUMOR CELLS
- Journal of Radiation Research and Radiation Processing Vol. 9, Issue 2, Pages: 65-68(1991)
- 作者机构：
  
  第二军医大学，上海
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：1991-05，
  
  Received：04 October 1989，
- 稿件说明：
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Zhao Fang, Zheng Xiulong. STUDIES ON THE EFFECT OF A NEW RADIOSENSITIZER CM ON THE DNase ACTIVITY OF IRRADIATED HEPATIC TUMOR CELLS. [J]. Journal of Radiation Research and Radiation Processing, 1991,9(2):65-68.
DOI：

Zhao Fang, Zheng Xiulong. STUDIES ON THE EFFECT OF A NEW RADIOSENSITIZER CM ON THE DNase ACTIVITY OF IRRADIATED HEPATIC TUMOR CELLS. [J]. Journal of Radiation Research and Radiation Processing, 1991,9(2):65-68. DOI：

摘要

本文报道了新型辐射增敏药甲硝唑氨酸（CM）及其与Ca

+2

结合后对肝癌H

22

细胞DNase作用，并观察了CM，CMCa及Ca

+2

和三者分别对受30 Gy γ线照射细胞DNase活力的影响。结果表明，CM浓度在10 mmol/L以下对H

22

细胞DNase有激活作用。以5 mmol/L时激活作用最强，在5 mmol/L以下随药物浓度的增加，激活作用随之增加，CM与Ca

+2

结合成CMCa后对细胞DNase的激活作用与CM相似，两者无显著差别（p

>

0.05）

CM、CMCa的这种激活作用与γ线照射后对DNase活力增高有叠加作用，而Ca

+2

对受照或非受照H

22

细胞DNase活力无明显的影响。上述结果表明，CM及其与Ca

+2

结合成CMCa后无论对受照或非受照H

22

细胞DNase均有激活作用。这种通过激活受照肿瘤细胞DNase叠加活力的增加、增强DNA破坏而提高肿瘤放疗效果，可能是其放疗作用的机制之一。

Abstract

The effects of a new radiosensitizing compound-metronidazolamic acid(CM) and its Ca

+2

chelation compound (CMCa) on the DNase activity of mouse hepatic tumor (H

22

) cells were observed.The effects of CM

CMCa or Ca

+2

at same molarity and their combination with γ-rays irradiation on DNase activity of H

22

cells were also observed respectively. The results showed that CM could activate the DNase activity to be increased as CM concentration increased below 5 mmol/L. The highest DNase activity was activated by CM at 5 mmol/L. The degree of activation between CM and CMCa had no significant differente (p

>

0.05)

whereas free Ca

+2

alone had no effect. The activation of combined CM or CMCa and radiation groups were greater than that of each given indep

endently (Fig. 3)

they possessed a coordinate activation. However free Ca

+2

still could not activate the DNase activity after γ-irradiation. From all the above results

it is suggested that CM or CMCa improved the tumor radiotherapeutic efficiency probable due to its activation the DNase activity of cancer cells which enhanced the DNA damage. It might be one of the radiosensitizing mechanism in tumor radiothorapy.

关键词

辐射增敏剂甲硝唑氨酸H22细胞脱氧核糖核酸酶

Keywords

RadiosensitizerMetronidazolamic acidH22 cellsDNase

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