PREPARATION OF SLOW RELEASE ANTICANCER DRUG BY MEANS OF RADIATION TECHNIQUE AND IT'S THERAPEUTIC EFFECT ON SOLD TUMOR OF MICE

Li Ximing; Shen Weiming; Liu Chengjie; Hu Xu

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PREPARATION OF SLOW RELEASE ANTICANCER DRUG BY MEANS OF RADIATION TECHNIQUE AND IT'S THERAPEUTIC EFFECT ON SOLD TUMOR OF MICE

更新时间：2024-11-05

- PREPARATION OF SLOW RELEASE ANTICANCER DRUG BY MEANS OF RADIATION TECHNIQUE AND IT'S THERAPEUTIC EFFECT ON SOLD TUMOR OF MICE
- Journal of Radiation Research and Radiation Processing Vol. 9, Issue 2, Pages: 90-94,78(1991)
- 作者机构：
  
  中国科学技术大学，合肥
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：1991-05，
  
  Received：08 December 1989，
- 稿件说明：
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Li Ximing, Shen Weiming, Liu Chengjie, et al. PREPARATION OF SLOW RELEASE ANTICANCER DRUG BY MEANS OF RADIATION TECHNIQUE AND IT'S THERAPEUTIC EFFECT ON SOLD TUMOR OF MICE. [J]. Journal of Radiation Research and Radiation Processing, 1991,9(2):90-94,78.
DOI：

Li Ximing, Shen Weiming, Liu Chengjie, et al. PREPARATION OF SLOW RELEASE ANTICANCER DRUG BY MEANS OF RADIATION TECHNIQUE AND IT'S THERAPEUTIC EFFECT ON SOLD TUMOR OF MICE. [J]. Journal of Radiation Research and Radiation Processing, 1991,9(2):90-94,78. DOI：

摘要

本文介绍利用低温过冷态辐射聚合制备慢释放抗癌药的方法。报告这种慢释放氟尿嘧啶药对小鼠实体肿瘤的治疗效果。对于可移植性615小鼠前胃鳞状上皮癌和可移植性昆明小鼠S 180肉瘤的抑制率分别为40%和96%，不仅有显著的治疗效果而且用药后毒副作用也有明显降低。

Abstract

In order to minimize the toxic effect of chemotherapy of malignant tumors

the authors use a method of radiation indued cast polymerization of hydrophilic monomer at low temperature for immobilization the anticancer drug

5-Fluorouracil

into the polymer matrix. The anticancer drug-polymer composite called slow release anticancer drug was used for treatment the transplantable squamous cell carcinoma in mice 615 and the transplantable sarcoma (S 180) in Kunming mice. There were marked difference between the treated group and the control group. That is the higher inhibition ratio and lower toxic effect were reported.

关键词

辐射聚合慢释放抗癌药化学疗法

Keywords

Anticancer drugSlow releaseRadiation polymerizationChemotherapy

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