With the rapid development of radiation sterilization, the radiation resistant polymer for medical use has become a hot research topic in both basic and practical point view. In this paper, the recent progress of medical radiation resistant polypropylene (PP) was reviewed. Not only the radiation degradation mechanism of polypropylene, but also the color change mechanism and the preparation of radiation resistant were involved. The paper focused on the preparation of radiation resistant polypropylene and the challenge in preparation of the medical material and its future development were discussed.Cited