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CHEN Wei; HE Ying; SHEN Xianrong; JIANG Dingwen; WANG Qingrong; HOU Dengyong; LIU Yuming; LI Kexian; LIU Qiong; QIAN Tiantian

doi:10.11889/j.1000-3436.2014.rrj.32.010203

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更新时间：2021-12-01

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- Journal of Radiation Research and Radiation Processing Vol. 32, Issue 1, Pages: 10203-010203(2014)
- 作者机构：
  
  1. （海军医学研究所）,上海,200433
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- DOI：10.11889/j.1000-3436.2014.rrj.32.010203
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CHEN Wei, HE Ying, SHEN Xianrong, et al. [J]. Journal of Radiation Research and Radiation Processing 32(1):10203-010203(2014)
DOI：

CHEN Wei, HE Ying, SHEN Xianrong, et al. [J]. Journal of Radiation Research and Radiation Processing 32(1):10203-010203(2014) DOI： 10.11889/j.1000-3436.2014.rrj.32.010203.

摘要

应用蛋白质组学方法筛选对低剂量g射线敏感的蛋白质,并采用双向凝胶电泳和基质辅助激光解析飞行时间串联质谱技术分离、鉴定不同低剂量g射线导致的小鼠血清差异表达蛋白。不同低剂量g射线照射后,对实验组与对照组的血清双向电泳图谱进行比较分析，通过质谱鉴定得到7个差异表达点，分别是载脂蛋白C-III、b珠蛋白、腮腺分泌蛋白、a2巨球蛋白前体、转甲状腺蛋白晶体结构H链、C1qc蛋白和丛生蛋白。提示低剂量g射线辐照能导致小鼠血清中某些蛋白表达发生变化。

Abstract

The aim is to find out the key proteins related with low dose radiation (LDR) by proteomic technology, which provided the theory foundation for LDR protection. Two-dimensional electrophoresis (2-DE) was performed on serum protein. Differential expression proteins were identified by matrix assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS) and database analysis. Compared with the control group, 7 altered proteins was definite in terms of apolipoprotein C-III, beta-globin, parotid secretory protein, alpha-2-macroglobulin precursor, mouse transthyretin, C1qc protein and clusterin. Some proteins related with LDR are found. It may provide some new explanations for the mechanism of LDR.Cited

关键词

低剂量辐射血清蛋白差异表达蛋白质组学小鼠

Keywords

Low dose radiationSerum proteinDifferential expressionProteomicsMouse

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Department of Pathology, the First Affiliated Hospital of Hunan University of Medicine

Hunan Provincial Key Laboratory of Dong Medicine, Hunan University of Medicine

Department of Basic Medicine, Yongzhou Vocational Technical College

Department of Histology and Embryology, Fourth Military Medical University

Department of Radiation Medicine, Fourth Military Medical University

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DOI：10.11889/j.1000-3436.2014.rrj.32.010203

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