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LIU Qiong; HE Yin; SHEN Xianrong; JIANG Dingwen; HOU Dengyong; LIU Yuming

doi:10.11889/j.1000-3436.2015.rrj.33.030204

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更新时间：2021-12-01

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- Journal of Radiation Research and Radiation Processing Vol. 33, Issue 3, Pages: 30204-030204(2015)
- 作者机构：
  
  1. （海军医学研究所防护医学研究室）,上海,200433
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- DOI：10.11889/j.1000-3436.2015.rrj.33.030204
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LIU Qiong, HE Yin, SHEN Xianrong, et al. [J]. Journal of Radiation Research and Radiation Processing 33(3):30204-030204(2015)
DOI：

LIU Qiong, HE Yin, SHEN Xianrong, et al. [J]. Journal of Radiation Research and Radiation Processing 33(3):30204-030204(2015) DOI： 10.11889/j.1000-3436.2015.rrj.33.030204.

摘要

为探讨血清AXL是否可作为电离辐射剂量估算的生物指标，本文研究了急性照射后不同时间点血清AXL浓度变化与电离吸收剂量的相关性，并分析了不同时间点AXL基线表达的稳定性。采用雄性C57BL/6小鼠为辐照对象，分3个时间点采样，每个时间点随机选取100只小鼠，再随机分为5组，每组20只：其中对照组1组，辐照组4组。辐照组小鼠接受60Co一次性照射，受照剂量分别为1、3、5和7 Gy，于照射前和照射后24、48、72 h留存血清样本，血清AXL浓度经定量细胞因子芯片检测与分析。结果表明，未照射小鼠AXL表达基线稳定，正常值范围为(186.6±44.20) pg/mL；辐照后24、48和72 h，血清AXL含量随吸收剂量增大而减少，且血清AXL含量ln值与吸收剂量呈线性相关，血清可作为电离辐射剂量估算的生物指标。

Abstract

To assess the usability of serum AXL as a possible biomarker for acute radiation exposure, the baseline level and variations induced by radiation of serum AXL were analyzed. Three hundred male C57BL/6 mice were randomly divided into radiation groups (n=240) and the control (n=60). After 60Co total-body irradiation at the dose of 1, 3, 5 or 7 Gy respectively, mice were sacrificed and their serums were collected at 24, 48, or 72 h separately. Serum AXL concentration were then analyzed by antibody array. The results suggested that baseline level of serum AXL expression hold steady (186.3±44.20) pg/mL. Moreover, serum AXL concentration is inversely related to the radiation dose within 72 h after exposure. This study uncovers a strong correlation between serum AXL concentration and radiation dose, and serum AXL has a consequential ability to estimate radiation exposure as biomarker.Cited

关键词

受体酪氨酸激酶细胞因子生物剂量计电离辐射

Keywords

AXLCytokineBio-dosimetryIonizing radiation

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DOI：10.11889/j.1000-3436.2015.rrj.33.030204

摘要

Abstract

关键词

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