STUDIES ON THE EFFECTS OF COPPER PUPURIN18 ON ERYTHROPOIESIS

XANG Yingsong; YANG Rujun; MENG Xiangshun; GAO Jianguo; LI Bailong

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STUDIES ON THE EFFECTS OF COPPER PUPURIN18 ON ERYTHROPOIESIS

更新时间：2023-04-07

- STUDIES ON THE EFFECTS OF COPPER PUPURIN18 ON ERYTHROPOIESIS
- Journal of Radiation Research and Radiation Processing Vol. 17, Issue 1, Pages: 41-44(1999)
- 作者机构：
  
  1.第二军医大学放射医学研究室　上海　200433
- 作者简介：
- 基金信息：
  
  The National Natural Science Foundation of China(39600077)
- DOI：
  CLC：
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XANG Yingsong, YANG Rujun, MENG Xiangshun, et al. STUDIES ON THE EFFECTS OF COPPER PUPURIN18 ON ERYTHROPOIESIS. [J]. Journal of Radiation Research and Radiation Processing 17(1):41-44(1999)
DOI：

XANG Yingsong, YANG Rujun, MENG Xiangshun, et al. STUDIES ON THE EFFECTS OF COPPER PUPURIN18 ON ERYTHROPOIESIS. [J]. Journal of Radiation Research and Radiation Processing 17(1):41-44(1999) DOI：

摘要

为了寻找再生障碍性贫血治疗药物，从四吡咯化合物中设计合成了铜紫红素18,观察铜紫红素18对受照射昆明种小鼠红系造血的作用。结果表明：铜紫红素18能明显促进造血干细胞（CFU-S）优先向红系祖细胞（CFU-E）转化；在恢复期也有提升WBC和骨髓有核细胞计数的作用。本结果提示，铜紫红素18作为再生障碍性贫血防治药物具有良好的发展前景，值得进一步研究。

Abstract

Attempts were afforded to search for new antiaplastic anemia drays from tetrapyrroles. Observation of the effects of copper purpurin 18, a representative one of the metal tetrapyrroles was synthesized by ours, on erythropoiesis in Kungming mice lethally irradiated. It was shown that copper purpurin18 preferably increased stem cells (CFU-S) into erythroidpregenitor cells (CFU-E) ,and increase WBC and nucleated cells of bone marrow significantly in the phase of recover. It suggested that there may be good prospect in developing new drugs for treatment of aplastic anemia with copper purpurin 18,and it was worth to further investigations.

关键词

辐射铜紫红素18造血干细胞

Keywords

IrradiationCopper pupurin 18Hematopoietic

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