FREQUENCIES OF ANEUPLOID AND DOMINANT LETHAL MUTATIONS IN YOUNG FEMALE MICE INDUCED BY LOW DOSES γ-RAYS

Yao Suyan; Zhang Chaoyang; Dai Lianlian; Gao Changwen

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FREQUENCIES OF ANEUPLOID AND DOMINANT LETHAL MUTATIONS IN YOUNG FEMALE MICE INDUCED BY LOW DOSES γ-RAYS

更新时间：2023-04-23

- FREQUENCIES OF ANEUPLOID AND DOMINANT LETHAL MUTATIONS IN YOUNG FEMALE MICE INDUCED BY LOW DOSES γ-RAYS
- Journal of Radiation Research and Radiation Processing Vol. 9, Issue 4, Pages: 214-218(1991)
- 作者机构：
  
  1.卫生部工业卫生实验所，北京
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Yao Suyan, Zhang Chaoyang, Dai Lianlian, et al. FREQUENCIES OF ANEUPLOID AND DOMINANT LETHAL MUTATIONS IN YOUNG FEMALE MICE INDUCED BY LOW DOSES γ-RAYS. [J]. Journal of Radiation Research and Radiation Processing 9(4):214-218(1991)
DOI：

Yao Suyan, Zhang Chaoyang, Dai Lianlian, et al. FREQUENCIES OF ANEUPLOID AND DOMINANT LETHAL MUTATIONS IN YOUNG FEMALE MICE INDUCED BY LOW DOSES γ-RAYS. [J]. Journal of Radiation Research and Radiation Processing 9(4):214-218(1991) DOI：

摘要

本文报道低龄雌鼠受到0.15—1.56 Gy，0.05 Gy/min ,60,Co γ射线照射后，过一定时间与正常雄鼠同笼。在胚胎满9.5—11 d时活杀孕鼠，观察其染色体异常胚胎发生率及显性致死突变率与剂量的关系。结果表明，在剂量为0.15 Gy时，其非整倍体胚胎发生率未见增加；在0.50 Gy以上时，似随剂量增加而增加。但三体胚胎的剂量效应关系不明显。观察到的显性致死突变率与受照剂量呈直线相关。在上述剂量范围内，显性致死突变率为5.59%。显性致死突变的效应比非整倍体胚胎的效应高。

Abstract

Relationship between aneuploid, dominant lethal mutaions and doses in young female mice induced by low doses γ-rays was examinated. The results suggest that the frequencies of aneuploid of embryos were not found increase at 0.15 Gy, but increases at over 0.50 Gy after irradiation in groups. The frequencies of aneuploid and dominant lethal mutations were increased with increasing doses and fitted linear relationship.The dose-response relationship of trisomic was not significant. The frequency of dominant lethal mutations induced by ,60,Co ,γ, irradiation is 5.59% .The effect of dominant lethal mutation is higher than that of the aneuploid.

关键词

胚胎非整倍体显性致死突变60Co γ射线

Keywords

EmbryoAneuploidDominant lethal mutationsγ-rays

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