EFFECTS ON OFFSPRINGS HEMOPOIETIC TISSUES AFTER γ-RAY CONTINUOUS IRRAOIATION OF THE MICE DURING MID-TERM GESTATION

Jiang Tienan; B. I. Lord; J. H. Hendry

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EFFECTS ON OFFSPRINGS HEMOPOIETIC TISSUES AFTER γ-RAY CONTINUOUS IRRAOIATION OF THE MICE DURING MID-TERM GESTATION

更新时间：2023-05-04

- EFFECTS ON OFFSPRINGS HEMOPOIETIC TISSUES AFTER γ-RAY CONTINUOUS IRRAOIATION OF THE MICE DURING MID-TERM GESTATION
- Journal of Radiation Research and Radiation Processing Vol. 13, Issue 2, Pages: 118-122(1995)
- 作者机构：
  
  1.中国医学科学院放射医学研究所，天津　300192
  2.Paterson　Institute　for　Cancer　Research,Christie　Hospital,　Manchester,　England
- 作者简介：
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Jiang Tienan, B. I. Lord, J. H. Hendry. EFFECTS ON OFFSPRINGS HEMOPOIETIC TISSUES AFTER γ-RAY CONTINUOUS IRRAOIATION OF THE MICE DURING MID-TERM GESTATION. [J]. Journal of Radiation Research and Radiation Processing 13(2):118-122(1995)
DOI：

Jiang Tienan, B. I. Lord, J. H. Hendry. EFFECTS ON OFFSPRINGS HEMOPOIETIC TISSUES AFTER γ-RAY CONTINUOUS IRRAOIATION OF THE MICE DURING MID-TERM GESTATION. [J]. Journal of Radiation Research and Radiation Processing 13(2):118-122(1995) DOI：

摘要

造血组织是辐射高敏感组织之一，胚胎动物的造血组织对辐射更为敏感。本文观察了持续性小剂量率γ射线照射妊娠中期母鼠，对出生子鼠股骨骨髓有核细胞数（BMC）、造血干细胞（CFU-S）数及其在股骨骨髓腔中分布状况的改变，和对造血组织基质细胞（CFU-F）的变化。本实验观察到正常小鼠股骨骨髓CFU-S分布，接近骨髓骨皮质的CFU-S浓度最高，约为41/10,5,BMC，近骨髓中心静脉窦CFU-S浓度最低，大约是22/10,5,BMC。,60,Co ,γ,射线从妊娠13 d到出生前持续性照射6 d，分为15 cGy/d剂量组和60 cGy/d剂量组，出生子鼠成长到8周龄时，可见到股骨骨髓中CFU-S的分布紊乱，特别是在接近骨髓皮质部分的CFU-S数量明显下降，股骨骨髓中CFU-S总数也明显下降，15 cGy/d组下降了20%, 60 cGy/d组下降了33%，骨髓基质中CFU-F数量在15 cGy/d组下降12%，而60 cGy/d组下降33%。统计学处理均有显著性差异。

Abstract

The radial distribution of CFU-S in the femur of a normal 8 weeks old mouse is shown and corresponds closely to Lord and Hendry. The highest concentration (about 41/10,5, cells) was near to the bone surface and the lowest (about 22/10,5, cells)was close to the central venous sinus which runs roughly along the longitudinal axis of the bone shaft. Continuous exposure to γ-rays for 6 d from 13d of gestation to birth had a smaller effect on the total femoral cellularity at 8 weeks of age, decreasing it by 12%~20%. The 15 cGy/d regimen caused a significant(20%) CFU-S deficit (,p,<,0.02) in the marginal zones. The 60 cGy/d schedule increased the deficit to a level (33%) and the change in the femoral CFU-S distribution after γ-ray irradiation is also shown. The 60 cGy/d schedule also reduced the fibroblastoid, CFU-F population, to 67% of control (,P,<,0.001). The 15 cGy/d reduced to 88% of control.

关键词

妊娠鼠造血干细胞子鼠γ辐射。

Keywords

Pregnant miceOffspring of miceγ-irradiation

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