COMPARISION OF MICRONUCLEUS FREQUENCY IN HUMAN LYMPHOCYTES IRRADIATED IN VITRO AND IN VIVO

Liu Yuanzhao; Gou Ying; Liu Mingyuan

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COMPARISION OF MICRONUCLEUS FREQUENCY IN HUMAN LYMPHOCYTES IRRADIATED IN VITRO AND IN VIVO

更新时间：2023-05-04

- COMPARISION OF MICRONUCLEUS FREQUENCY IN HUMAN LYMPHOCYTES IRRADIATED IN VITRO AND IN VIVO
- Journal of Radiation Research and Radiation Processing Vol. 13, Issue 2, Pages: 123-125(1995)
- 作者机构：
  
  1.北京医院放疗科，北京　100730
- 作者简介：
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Liu Yuanzhao, Gou Ying, Liu Mingyuan. COMPARISION OF MICRONUCLEUS FREQUENCY IN HUMAN LYMPHOCYTES IRRADIATED IN VITRO AND IN VIVO. [J]. Journal of Radiation Research and Radiation Processing 13(2):123-125(1995)
DOI：

Liu Yuanzhao, Gou Ying, Liu Mingyuan. COMPARISION OF MICRONUCLEUS FREQUENCY IN HUMAN LYMPHOCYTES IRRADIATED IN VITRO AND IN VIVO. [J]. Journal of Radiation Research and Radiation Processing 13(2):123-125(1995) DOI：

摘要

报道1例淋巴瘤病人进行全身分次X射线照射后，发现离体与整体照射诱发的微核率无显著性差异（,p,>,0.5）。经回归分析表明，不仅配合的模式相同，而且同一指标的回归系数也相当接近。结果表明，在一定的剂量范围内，离体与整体照射的微核剂量效应相同。这使人外周血淋巴细胞微核率有可能作为估算事故受照人员辐射生物剂量的指标。

Abstract

A Lymphomas case was treated with whole body irradiation. The results showed that micronucleated cell frequency and micronucleus frequency were very similar between the blood samples irradiated in vitro and in vivo. The differences were not singnificant (,p,>,0.5). The patterns of the curves obtained from regression analysis were identical, and the differences among the two regression equations of the same parameter were not singnificant, it is considered that dose effect was almost the same between the blood samples irradiated in vitro and in vivo in certain dose extent. The micronucleus frequency of human peripheral blood lymphocytes could be applied as a supplementary criterion fordose estimation to irradiated human at early stage of nuclear accident.

关键词

微核率离体照射整体照射淋巴细胞

Keywords

Micronucleus frequencyIrradiation in vitroIrradiation in vivoLymphocyte

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