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YAO Qingwan1; 2; LIU Qingfang1

doi:10.11889/j.1000-3436.2012.rrj.30.120405

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更新时间：2021-12-01

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- Journal of Radiation Research and Radiation Processing Vol. 30, Issue 4, Pages: 215-220(2012)
- 作者机构：
  
  1. 1（苏州大学医学部公共卫生学院）,苏州,215123
  2. 2（昆山疾病预防控制中心昆山）,215301
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- DOI：10.11889/j.1000-3436.2012.rrj.30.120405
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YAO Qingwan1, 2, LIU Qingfang1. [J]. Journal of Radiation Research and Radiation Processing 30(4):215-220(2012)
DOI：

YAO Qingwan1, 2, LIU Qingfang1. [J]. Journal of Radiation Research and Radiation Processing 30(4):215-220(2012) DOI： 10.11889/j.1000-3436.2012.rrj.30.120405.

摘要

探索舒肝丸辐照灭菌剂量，及辐照后其对大鼠肝功能的影响，为辐照灭菌舒肝丸的临床安全应用提供实验依据。测定舒肝丸初始污染菌，经钴源辐照灭菌后，测定D10值及SD；用辐照灭菌后的舒肝丸对大鼠进行灌胃给药，测定大鼠血液生化指标，观察辐照的舒肝丸对大鼠生化指标的影响。本次实验舒肝丸初始污染菌范围在50－1800 CFU/g，D10值为1.81 kGy，经计算辐照灭菌剂量为11.322 kGy，确定灭菌保证水平为10-3，辐照后的舒肝丸对实验大鼠肝功能指标无明显损害作用。舒肝丸辐照灭菌剂量为11.322 kGy，经12 kGy辐照后的舒肝丸对实验大鼠肝功能指标无明显损害作用。

Abstract

The absorbed dose of irradiation sterilization for Shu-Gan Wan and the effects of irradiated Shu-Gan Wan on rat liver function was investigated to provide the scientific basis for its clinical safety applications. The amount range of contaminating bacteria in original Shu-Gan Wan was determined before irradiation and the D10 & SD were calculated after irradiation. The irradiated Shu-Gan Wan were given to the rats and the biochemical items of liver were measured before and after-irradiation. The experimental results show that the amount range of contaminating bacteria count of the Shu-Gan Wan is 50-1800 CFU/g, the D10 value is 1.81 kGy and the minimum bactericidal dose has been calculated to be 11.322 kGy. The 60Co radiation dose for sterilization of Shu-Gan Wan has been suggested to be 11.322 kGy and irradiated Shu-Gan Wan has no significant damage to liver function of the rat.Cited

关键词

舒肝丸辐照灭菌D10值灭菌剂量肝功能影响

Keywords

Shu-Gan WanRadiation sterilizationD10valueBactericidal doesImpact on liver function

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DOI：10.11889/j.1000-3436.2012.rrj.30.120405

摘要

Abstract

关键词

Keywords

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