最新刊期
      期 1 ， 1986
      • Gao Fengming,Yu Yannan,Jiang Hanying
        Vol. 4, Issue 1, Pages: 1-8(1986)
        摘要：The aim of this paper is to observe whether estrogenic hormones are carcinogen and synergistic effects appear when γ ray and estrogenic hormones are used simultaneously.One hundred and eighty one female wistar rats were performed an operation on subtotal uterectomy at the upper one third of fused uterus (cervix) 17 days before beginning of the experiment, and then were divided into 4 groups with 40~46 rats in each group as follows:Group 1: whole-body γ ray exposure was given with 300 rads, then estradiol valerate (E, 10 mg/kg, bw) and hydroxyprogesterone caproate (P, 1250 mg/kg, bw) were injected intramuscularly one day following γ ray exposure and once with interval of 2 weeks for 24 times.Group 2: whole-body γ ray exposure was given only with the same dose as that in group 1.Group 3: EP was injected only with the same dose as that in group 1.Group 4: Control group without any treatment.Some results were obtained as follows:Incidences of tumours in group 1~4 were 61.5%, 90.9%, 30.8%, and 10.3%respectively, there were significant or very significant differences in group l~3 compared with control group (p<0.05 or <0.01) . Average latent periods of tumours in the four groups were 208~404 days.From the point of view of tumour induction concerned, in group 1 and 2, although most of them derived from pituitary gland and mammary glands, but quite different types of tumour observed.In group 2, the main type of tumours was benign fibroadenomas of mammary glands, with the ratio of malignant to benign tumours being 0.5. However in group 1, the main type of mammary tumours was malignant, with the ratio of malignant to benign tumours being 5.5; and furthermore, the incidence of pituitary gland tumours was much higher than that in group 2 or 3 (46.2%, 6.1%, and 26.9% respectively) .Besides tumours, there were a number of pyometra in group 1~3, especially in group 1 and 3 with very high incidences of 78.6% and 81.4% respectively.  
        关键词：Wistar female rats;Estradiol valerate;Hydroxyprogesterone caproate;Mammary tumours;Pituitary gland tumours;Pyometra   
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        发布时间：2023-04-23
      • Wu Zhili,Chen Xinwei,Zhang Jiashan
        Vol. 4, Issue 1, Pages: 9-14(1986)
        摘要：Six kinds (yellow, green, light blue, purple, grey and blue) are chosen from sixty kinds of dyeing polyethylene terephthalate films, and the absorption spectrum, the wavelength of optical absorbance reading, the dose range and the precision limits for these films are studied. The stability of these systems before and after irradiation, the effects of temperature and relative humidities during irradiation on the response are exanined. The response curves and thier experience expression are give under controlled experimental conditions. The results show that these films can be applied to routine dosimetry in radiation processing with gamma radiation. The yellow film is the best one of the six and its dose range is 0.1~3.5 ×103kGy.  
        关键词：Dyeing polyethylene terephthalate films dosimeter;60Co γ-ray response characteristics;Effects of environmental facter;stability   
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        发布时间：2023-04-23
      • Wang Mingjun,Du Cong,Dong Liangchang,Ma Zueteh
        Vol. 4, Issue 1, Pages: 15-23(1986)
        摘要：In present work, in order to obtain the quantitative regularity the effects of molecular weight of methyl-vinyl silicone rubber (MVSR) on the values of various crosslinking parameters have been investigated with the theory of radiation crosslinking. From obtained experimental results, it can be found that the straight linear relationship exits between the weight average molecular weight and the parameters, such as gelation dose (Rg) , total degree of cross-linking per unit dose (q0), total degree of degradation per unit dose (α0) , degree of cross-linkling in sol per unit dose (q0(s) ) , degree of degradation in sol per unit dose(α0(s) ,degree of cross-linking in gel per unit dose (q0(g) ) , degree of degradation in gel per unit dose(α0(g) ) , total cross-linking index (γ) , cross-linking index in sol (γ(s) ) , cross-linking index in gel(γ(g) ) ,α0/q0, α0(s) /q0(s) α0(g) /q0(g) and Gseiss Value, but the Gcross Value is proportional to reciprocal of the weight average molecularweight, we getIt is seen that the higher the initial molecular weight of MVSR, the faster the rate of cross-linking is. There is converse effect for polyether acrylic isocyanate and the like, but the straight linear relationship between molecular weight of oligomer and the value of various cross-linking parameters still exists.In this paper, the effect of different isocyanate structure on the activity of the terminal acrylic group of oligomer was also investigated and the activity order is as follows:polyether acrylic hexa-methylene isocyanate > polyether acrylic toluene isocyanate > polyether acrylic 4,4'-diphenyl methylene isocyanate.  
        关键词：Different molecular weight;Cross-linking parameter;Straight linear ralationship;Quantitative regularity;Gcorss value;Oligomer of different isocyanate Activity of terminal acrylic group   
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        发布时间：2023-04-23
      • Ye Shuhua,Luo Cuihua,Liu Qihua,Wang Xinli
        Vol. 4, Issue 1, Pages: 24-26(1986)
        摘要：This article reported the methods of rabbit erythrocytes rosette-formation and zymosan complement complexes rosette-formation in vitro terts in rats and com- pared the percentage of T,B cells in periphery blood between two groups of rat fed with irradiated and un-irradiated food.There was no significant difference between two groups in both rosette-formation tests and sex.The results above-mentioned indicated the irradiated food was secure to surface marks on immune cells in body.  
        关键词：Peripheral T,B cells;Rabbit erythrocyte rosette formation;zymosan complement complex rosette formation   
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        发布时间：2023-04-23
      • Zhang Zhicheng,Zhang Manwei
        Vol. 4, Issue 1, Pages: 27-34(1986)
        摘要：An idea about influence of excited molecules on positronium (Ps) formation is proposed, it says: (1) in addition to the excess electrons, some excited molecules created in the spur can also promote the formation of Ps; (2) the excited molecule reaction may exert an influence on the probability of Ps formation by some way depending on the reaction mode (quenching of excited energy or transport of electron from excited molecule to additive) . According to the competitive reaction mechanism in the spur, a relationship correlating the probability of O-Ps formation(I3) with the additive concentration (which is included in F and F*) is obtained for binary systems (See Eq(11)) . By this equation, the theoretical fittings are made for some mixtures consisting of a nonpolar substance and an additive such as CS2, SF6, C2H5Br, CCl4. From the fitting parameters, some valuable information about the electron affinity of the additive and the ionization potential of the excited molecule are obtained. Furthermore some "knotty problems" in positronium chemistry are satisfactorily interpreted.  
        关键词：Competitive reaction;Excited molecule reaction;Probability of Ps formation;Ionization potential of the excited molecule;Electron affinity of the additive   
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        发布时间：2023-04-23
      • Lang Shuyu,Zhang Zhonglun
        Vol. 4, Issue 1, Pages: 35-41(1986)
        摘要：The model BPLL readout equipment of lyoluminescence dosimeter has been constructed in our lab. The D. C. current integration method has been employed in the equipment. The model GDB-52 photomultiplier has been selected as a light detector, the model NWF-02 A weak current amplifier and a voltage-frequency converter have been used. The sensitivity of the equipment can be regulated and its stability in 8 hours is satisfactory for dose measurement, the standard deviation of the mean of 48 measured values is ±0.4%. The glutamine lyoluminescence dosimetric characteristics for radiation processing has been studied on the model BPLL readout equipment. The range of linear dose response is in the 102~104 Gy. The dependence of light yield on the temperature of solvent and the mass of samples and the storage effect of samples after irradiation are disscused.  
        关键词：lyoluminescence;current integration method;glutamine;readout equipment   
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        发布时间：2023-04-23
      • Zhu Younan,Weng Chenlian,Zhang Jiashan
        Vol. 4, Issue 1, Pages: 42-47(1986)
        摘要：In this paper, we study the reaction mechanism of 5'-GMP releasing the inorganic phosphate (Pi) induced by γ-ray. It is proved that hydroxyl radical produced by water radiolysis is the main active species which induct 5'-GMP releasing inorganic phosphate and H atom has also some contribution for inorganic phosphate release from 5'-GMP. It is measured by the competition kinetic method that the rate constants of the reaction of OH radical with 5'-GMP and 5'-GMP are 1.2×108(mol/L) -1S-1 and 5.1×109(mol/L) -1S-1, respectively.  
        关键词：5'-GMP;Releasing inorganic phosphate;Scavenger;Rate constant of reaction   
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        发布时间：2023-04-23
      • Zhao Bingxi,Jiang Yi,Bai yuhua,Wang Fengyin,Yu You,Jang Suying
        Vol. 4, Issue 1, Pages: 48-53(1986)
        摘要：This paper introduced the D10 value of colon bacillus and golden staphylococcous on RMB and Calculated their SD (Dose sterilization) . This paper also introduced the effect of RMB'S property by γ-ray irradiation The D10 value of Colon bacillus is 2.33×102Gy and the D10 value of golden staphylococcus is 2.02×102Gy, It's DQ is 1.03×102Gy. The SD of RMB is 7.0×102Gy, and maximum dose is 5×104Gy, when the multiple of loss vigour is 103. Since, when the RMB is irradiated on the dose of SD value 7.0×102Gy, the RMB's good effect of sterilization may be arrived by irradiation and the radiation have not produced the Clear wreck of RMB. So that the time of RMB usage will have not been influenced  
        关键词：Radiation sterilization;loss dose of ten multiple;Dose sterilization;Multiple of loss Vigour;Tensile strength;Withstand knead action;Withstand fold;Degree of white;Intransparency   
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        发布时间：2023-04-23
      • Su Zhaozhong,Luo Zuyu,Guo Lanping
        Vol. 4, Issue 1, Pages: 54-59(1986)
        摘要：The use of Viral probes to study DNA repair processes in mammalian cells has demonstrated its prodigious advantages. Expressing cellular repair functions in viral DNA greatly simplifies the strategy of investigation. The cellular constitutive repair activities have been probed as host cell reactivation and recombinational multiplicity infection reactivation by double-stranded DNA viruses such as Herpes Simplex Virus, adenovirus and SV 40. Single-stranded parvoviruses have been employed successfully to probe inducible cellular repair or recovery processes. It has been shown that an error-prone recovery activity resembling "SOS" response in E. coli may be induced in mammalian cells by a series of DNA-damaging agents. The inducing signal resides in DNA damage itself. Some DNA damages such as apurinic or apyrimidinic site may serve as the proper substrate of the induced repair function.  
        关键词：Parvovirus;Viral Probe;SOS repair;Host cell reactivation;Multiplicity infection reactivation;Post-replicative DNA repair;Inducible error-prone repair   
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        发布时间：2023-04-23
      • Zhen Xiulong,Yang Lixi,Gao Jianguo,Zhu Yuuo,Zhuo Fang,Liu Nan
        Vol. 4, Issue 1, Pages: 60-61(1986)
        摘要：The compound containing nitro group(e. g. misonidazole and metronidazole or flagyl) is a electron-affinic sensitizer which now improve better radiosensitiveness of hypoxic cell in solid tumor. However, neurotoxicity has limited its clinical use. In order to enhance its radiosensitizing effectiveness and reduce its neurotoxicity, a bifunctional compound-metronidazole derivative(CM) had been synthesized which had a tumor-affinic property and radiosensitize hypoxic cells. A series of analyses (e. g. m. p determination, TLC, paper electrophoresis and UV, IR) proved this synthetic compound to be a metronidazole derivative(CM) . Its molecular formula is C18H23O10 N7•1/2 H2O• Twelwe batches of this compound has been synthesized, and its purity was 98%, the synthetic method was stable. when labeled with 99mTc, it produced 99mTc-CM which could concentrate and maintain a high concentration in tumor in mice bearing S180 within 24 hours after iv injection. The radioactivity ratio of 99mTc retained in tumor with that of brain and muscle was 10~16 and 5~7 respectively, suggesting that 99mTc-CM had a strong tumor-affinic property. Because of its lower concontration in the brain, its neurotoxicity was decreased. In LD50 experimments, it indicated that its toxicity was lower than that of the original compound "flagyl" . when CM was chelated with Ca++ to form CMCa and ip into S180 bearing mice, after which the mice were locally irradiated with γ-ray under tumor acute local hypoxic condition, then the results indicated that the growth inhibiting effect on S180 in irradiated group with CMCa was strronger than irradiated (R) group alone. The tumor was inhibited by 77.4% within 10 days and higher than that of R group (p<0.05) . Its radiosensitizing enhancement ratio (SER) was 1.89 and its radiosensitizing effect was stronger than that of metronidazole. Therefore, CM had a obvioug radiosensitizing action.  
          
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        发布时间：2023-04-23
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