最新刊期
期 3 ， 1988
- 摘要：The relationship between radiation doses and its biological effects in lymphocytes was used as one of the most sensitve methods in early clinic work. The investigation of the change of activity, mortality, chromosome aberration, rosette formation, cell membrane and DNA molecule in lymphocytes was performed in different laboratories.Lymphocyte subpopulation was induced by PHA, ConA, PWM and LPS respectively. The radiation effects on the transformation in the subpopulation was studied. More research work in T-lymphocytes stimulated by PHA has been done. In our laboratory it demonstrated that PWM-induced and ConA-induced lymphocytes was more sensitive to radiatiation, both of them decreased the effects of help B lymphocytes transformation. PHA-induced lymphocytes was less sensitive. While the effect of radiation on LPS-induced Lymphocytes was not very obviousThe study of lymphocyte subpopulation and the radiation effect on it by using monoclonal antibody technique is to be carried out, then the effect of radiation on the main chains in immunity would be illustrated.Study of radiosensitivity of lymphocytes in various patients is beneficial to understanding defects in immunity and helpful of in design of more effective radiation regimes in some leukemia patients.关键词：PHA;ConA;PWM;LPS;Monoclonal antibody
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发布时间：2023-04-23 - 摘要：The structure and constitution of plasma-polymerized film of C3F6(PPHFP) have been investigated by using ESCA, 19F-NMR and IR. It was observed that the PPHFP film had high degree of branching, and almost 57% of the tetracarbons in the polymer were bounded with CF3 group. It was also found that the constitution of the polymer changed greatly at high power and formed mainly relatively long Si-O-Si chain with and/or without F atoms.关键词：Plasma-polymerization;Hexafluoropropene
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发布时间：2023-04-23 - 摘要：This paper studies the dosimetry for commissioning of a cobalt source equipment in Shanghai Irradiation Centre using the aqueous ferrous sulphate dosimetry. In the condition of the movement irradiation the dose distribution in the container, at which three boxes of the irradiation product are consolidated, was described, and two-dimensional map of dose distribution was given. The dose uniformity ratio measured for the containers equals 1.27±0.04 in the air, 1.32±0.04 in the transfusion pouches, 1.71±0.06 in the potatoes, respectively, and it has been discovered that these values can be estimated roughly by the bulk density of product in the boxes, ρ (kg/m3) :The calibration function of equipment, i. e. the relationship between the reciprocal of the conveyor speed and the dose values of
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发布时间：2023-04-23 - 摘要：The article reported four acute 60Co radiation accidents involving eleven victims in 1986. The victim of two accidents were evaluated after exposure for 24 hours, while those of other two accidents were determined after exposure for 48 hours. The cytochemical estimation of acid phosphatase and alkaline phosphatase activities in peripheral lymphocyte and granulocyte established in the past were adopted for the estimation of the dose received by the victims. The lowest dose estimated by the acid phosphatase and alkaline phosphatase activities was around 0.10 Gy, but the highest dose evaluated was about 1.90 Gy. The advantages about cytochemical estimation of LAP and ACP activities and the effect of taking radioprotective agent after exposure on the cytochemical estimation of ACP activity were discussed preliminarily.关键词：Radiation accident;Biological dose;Cytochemistry Acid phosphatase Alkaline phosphtase.
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发布时间：2023-04-23 - 摘要：The purpose of this study is to ascertain 147Pm retention in organism and its radiogenotoxicological effect induced by different doses. The dynamic retention of radioactivity in the body showed that iv different doses of 147Pm were all selectively and chiefly localized in liver and skeleton.Studies indicated that the chromosome aberration rates were elevated when the radioactive doses of 147Pm were increased. It showed a linear relationship between radioactive doses and effect:Internal contamination of 147Pm can be induced 4 chromatid breakage in one cell. This phenomenon might be due in part to nonuniform irradiation of bone marrow cells with local deposition of 147Pm. In addition, among the types of aberrations induced by 147Pm were predominantly of chromatid type, accompanied with a few chromosome breakage and translocation.The ability of 147Pm to induce SCEs has been investigated using IUdR labelling methods. A statistically significant elevation of SCEs was observed after 147Pm injection. The number of SCEs per cell in bone marrow cells were always higher in mice when the animals were maintained on the radioactive dose of 0.001 µCi/g level of 147Pm.We observed the injurious effects of 147Pm, using micronucleus rates in bone marrow cells. The results showed that obvious increase of micronucleus rates could be induced by 147Pm wih low dose as 0.005 µCi/g. While the peak value appeared at 1.34% after injecting 5 µCi/g of 147Pm for 24 hrIn general, the induction of chromosomal alterations by 147Pm radiation is probably the most readily discernible early manifestation of radiation damage to proliferating cells. The threshold dose of 147Pm to induce chromosome aberration was only 0.001 µCi/g. This value was lower than ALI of 147Pm, as reported by ICRP publication.关键词：Fission product 147Pm;Retention;Radiogenotoxicological effect;Chromosome aberrations;SCEs
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发布时间：2023-04-23 - 摘要：The effect of 60Co γ-rays on lymphocytes induced by Con A and LPS and the relationship between these two groups of cells were investigated by means of 3H-TdR incorporation. The study showed that in vitro, Con A cells were able to promote the inducing effect of LPS to B cells. When Con A cells were irradiated by 10 Gy γ-rays, the 3H-TdR incorporation value reduced significantly and the stimulating effect of Con A cells on LPS cells disappeared. Having been irradiated by γ-rays, LPS cells were not able to be stimulated by normal Con A cells. When the groups of cells were incubated together after irradiation, the synergistic function disappeared, furthermore the suppressive effect of Con A cells on LPS cells emerged. When these two groups of cells were investigated by means of agar culture, the suppressive effect of 10Gy γ-rays on lymphocytes colony formation was more obvious Tests on 8 patients who were suffering from carcinoma of nasopharynx showed that after a course of treatment with 60Co γ-rays, the incorporation value in Con A cells became much smaller, the stimulating effect of ConA cells on LPS cells disappeared. LPS cells could not be stimulated by normal Con A cells. The study demonstrated that the radiosensitivity of Con A cells was higher than that of LPS cells.关键词：ConA-induced lymphocyte;LPS-induced lymphocyte;3H-TdR incorporation.
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发布时间：2023-04-23 - 摘要：Radiation induced graft copolymerization of methyl methacrylate onto gelatin (by means of γ irradiation) has been investigated. Grafting reaction was carried out in aqueous solution. Results of experiments showed that the grafting percentage and the efficiency of grafting increased with the increase of reaction temperature and reaction time at the first stage. But they dropped when the reaction temperature and reaction time exceeded some certain values. The molecular weight of grafted side chains in obtained copolymers was found to be as high as 105.关键词：Radiation graft copolymerization;Irradiation;Gelatin;Methyl methacrylate
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发布时间：2023-04-23 - 摘要：SUMMARY. In this paper, our investigatigation results shown that the main characteristics of hemorheology effects were two-way change in blood viscosity, after whole body ir radiation for once with large dose ——first increase and then decrease.With the developement of radiation damage, there was a ea viscosity in eayly period with an average value which was 47.84% higher than that before ir radiation. But it varied with differences in sources of animals, radiation doses, shear stress rate, and souyce of blood关键词：Hemorheology;Blood viscosity;Apparent viscosity
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发布时间：2023-04-23 - 摘要：Human peripheral blood lymphocytes in vitro were irradiated by 60Co-γ -rays with 0.0489-0.524 Gy. By using UPG staining technique, the dose response relationships of chromosome aberrations were studied. The analysis of exclusively M1 cells, revealed surely aberration scored yields as compared with the results of the conventional method. The data of dicentrics plus centric rings of M1 cells give a good fit to linear or linearquadratic model in this dose range, and the data of acentics give a good fit to linear model. Finally, the results were discussed with regard to the application of dicentrics olus centric rings and acentrics for a cytogenetic dosimetry after exposure to low levels of ionizing radiation.关键词：Low-dose;Chromosome aberration;Acentric fragment;Dicentrics;Dose-response curve;UPG
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发布时间：2023-04-23 - 摘要：The Nan Feng Mandarin is a special native product of Jiangxi province in China, It's characterized by thin rind with few pits, much juice without dregs, good taste of sweet, fragrance and sour in goden color. However it can not be stored for a long time because of its thin rind and much juice. This paper has studied the effect of the radiation on the preservation of the Nan Feng Mandarin. The results showed that when the mandarin was stored at a room temperature for 100-120 days and irradiated at a low dose of 60Co ray, the rate of good one was up to the 80%, and 10-15% highter than that of the controlled Mandarin. But any distinct changes of main chemical compositions of the irradiated Mandarin haven't been found by examining. In addition, this paper has also preliminarily shed light on the mechanism of the radiation on the presevation of the Nan Feng Mandarin.关键词：Storage of fruits;The Mandarin;Radiation preservation;Irradiated Mandarin;Mechanism of irradiation
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发布时间：2023-04-23 - 摘要：The reverse recovery time of a silicon epitaxial high current diode with p+ nn+ type is substantially reduced by irradiation with 1.2 MeV electons, while the forward voltage drop of the device is maintained within nominal ranges. The present process technology is provided by positioning the diode semiconductor having soldered joint to the holder but still unsealed with the cap with the major surface adjoining the anode region of the device for exposure to a radiation source, and thereafter the device is irradiated by electrons at room temprature. The electron flux is about 5×1013 to 9×1014e-/cm2 and most desirably about 3~5×1014e/cm2. The electrical characteristics of the device were measured before and after irradiation. The irradiated devices sealed with the cap were stored at 150℃ and were tested electrically for a period of 240 hours. The irradiated devices have good characteristics. Now the present process technology have introduced into production.关键词：Electron irradiation;Sillicon epitaxial switching diode;Reverse Recovery time;Forward voltage drop
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发布时间：2023-04-23 - 摘要：Serval questions concerning absorbed dose have been studied. The mass energy-absorption coeffients Uen/ρ for some traditional mixtures are reported, the linear relations between the H percent of animals, plants and other organic materials and their Uen/ρ values are found out, it's correlation coefficient r is 0.9999, for the above materials, the element composition of ash are analyzed and their Uen/ρ are tabusted, their equivalent has been studied, finally, the restriction on
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发布时间：2023-04-23 - 摘要：The micronucleus assay has been considered as a fast method for determination of the chromosome aberration. It was shown in our earlier study that the micronucleus frequency was increased with the radiation doses in certain range, no matter what the radiation source is (x-rays, γ-rays and neutron). We proved firstly that micronucleus frequency induced by irradiation between in vivo and in vitro coincided well. That was the evidence for extrapolation value of the radiation dose in human from micronucleus graduated curve in vitro. Furthermore we got good result when it was used in a patient exposured accidently. This case was as follows:Mr. Wang, male, was irradiated by 60Coγ-rays in an accident on 1st September, 1980. The frequency of micronuclei was found 87‰ 2.5 hrs after irradiation in cultured blood. The table showed the dose-response relationship from 4 healthy blood donors in vitro. The curve could be described by a linear-quadratic model Y=4.0271+ 15.3024 X (Y—micronucleus frequency, ‰: X—irradiation doses, Gy) with the dose range from 0.2 to 6 Gy, the correlation coeffecient r=0.994. From this model, we estimated that the irradiated dose received by this patient was 5.42 Gy. It was close to the dose from either physical calculation (5.22 Gy), or chromosome aberration, or other biological dosimeter. We consider the micronucleus assay can be used comletely as a biological dosimeter for patients exposured by higher dose. Although the sensitivity is less than that of chromosome aberration, it is less time-consuming, less expensive procedure and very useful to examine the large number of samples, especially in the nuclear accident.
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发布时间：2023-04-23
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