摘要:The damage of capillary wall is the important cause of hemorrhage induced by radiation. Experiment showed previously that "8401" : 3-(3, 4, 5-trimethoxphenyl) -Propenoic acid ethylene diamine salt increased platelet number of the ir radiated mice. This paper observed the "8401" effect of different dose on influence of proliferation of the endothelial cells. The cultured cells of R22-25 were irradiated with 60Co r-ray (15 GY) at room temperature, then the Cells with an initial density of 3.5×105 cells/ml were plated on twelve dishes and 1-5 µg of "8401" were added into two dishes each (exeastt tho dishes as control.) By the seventh days after platting cells, each dish were trypsmized and counted with a blood counter. The result was: 1 µg group obtainedg cells count of 1.86×105 cells/dish 2 ug group-2.17×105 3 ug group-2.21×105 respectively, but control group is 1.23×105 cells/dish. The cells count in "8401" group was much higher than controlt (p<0.01). The results show that "8401" of a certain dose an stimulate growth of the irradiated endothelial cella and "8401" seem to promote proliferation of the endothelial cells in case of the endothelial cell injury.
摘要:The animals used in this study were male Wistar rats, 1.5 month old. All the animals were randomly divided into 12 groups, with 50 rats per group. The obser vation period after injection of a single dose of 125I of 13lI was two years blood sample were drawn from every animal heart under ether anaesthesia. The levels of T3, T4 and r-TSH in serum were assayed and the relative thyroid weight (i. e. ratio of thyriod weight and b. w.) was estimated. All of the parameters just mentioned above, compared between 125I-and 131I-groups.The experimental results showed that, the relative thyroid weight in the experimental groups decreased to the level which is 80% or 60% of control. The Ratios of equivalent dose of 125I and 131I were 1.5 and 1.2 respectively. From the biological effect point concerned, comparing the serum levels of T3, T4 and r-TSH in 125I and 131I groups, the ratios of equivalent dose are 2.1, 19 and 4.5 respectively.As mentioned above, the results indicated that for the 125I required 1,2-19-fold as many doses as 131I did.
关键词:Iodine-125;Iodine-131;Rats;Thyroid Ratio of equivalent dose
摘要:In this paper, the crosslinking PVC of insulation materials, especially the selection of multifunctional monomers and plasticizers has been investigated. The effect of radiation crosslinking PVC mixed with various multifunctional monomers and plassticizers has also been studied, the effect of the amount of various multifunctionl monomers and. plasticizers and of radiation dose, gel fraction, volume resistivity, all were studied, and loss weight after thermal aging and mechanical property of crosslinked PVC was determined as well. The crosslinked PVC insulation materials properties related with various monomers and plasticizers have been measuped. The variety and amount of multifunctional monomers and plasticizers were evaluated and preliminarily the various properties of PVC was discussed summarily.
摘要:Change of mechanical strength, thermal properties, and IR spectroscopy were studied for the γ ray irradiation of isotactic polypropylene under various conditions, such as vacuum or air or at room temperature.The change of crystalinity was calculated from the IR spectroscopy and the change of melting point was measured too. And the effects of storage time were compared.For irradiation under vacuum, the G value of crosslinking and scission were calculated by measuring gel fraction as follows:There was a significant decrease in the tensile break stress and strain of irradiated polypropylene in air for all doses but slight decrease in stress and strain of irradiated polypropylene in vacuum.
摘要:By using four methods of data processing, several kinds of biological endpoints (LD50/5 day; LD50/30day; weight loss of thymus; 3H-TdR incorporation of bone marrow DNA; specific activity of bone marrow DNA; synthetic cells of Bone marrow DNA and dicentric yield of bone marrow cells) have been analyzed. The preliminary results indicate that combined effect of simultaneous exposure with fission neutron and γ-rays are additive in nature for above-mentioned endpoints.
摘要:(1) The actual G values of gas radiolytic products of TBP (saturated with N2 and air) were obtained when the absorbed dose approaches to zero. The formation mechanism of gas radiolytic products has been discussed.(2) The energy transfer kinetics of TBP-DPSO system under γ-irradiation has been investigated. The kinetic parameter obtained by determining the G values of acid products is equivalent to that of gas radiolytic products of TBP.(3) The mechanism of formation of hydrogen under γ-irradiation bas been discussed. It is evident that there are two different pathways of formation if hydrogen exists. One may be molecular process taken place in spur and the other may be hydrogen abstraction reaction initiated by H atom.
摘要:In the process of radiation crosslinking of silicone rubber (SR), the relationship between sol fraction (S) and irradiation dose (R) does not conform to Charlesby-Pinner's formula, because α=α1+α0R assumed by Charlesby can not be established for SR. Generally, the exact equation may be described as follows(1)Therefore, the relation between S and R for radiation crosslinking of SR can be obtained(2)The influential factor is complicated for the dose exponent β, and molecular attraction between macromolecules and flexibility of main chain of polymer are important. If above factors were influenced, β value can be changed. In this paper, the effect of molecular weight of polymer, side-group, filler and filler quantity on β value and other crosslinking parameters were investigated.Considering A is smaller in formula (2), we have(3)By plotting with lnR against lnR, the value of B and β can be obtained from the intercept and the slope. Then, by plotting with against R, the linear relationship between them can be obtained.Also, by plotting with lnS against lnR, and when lnS→O, gelation dose (Rg) can be obtained.Combining with(4)We can calculate the values of various crosslinking parameters
关键词:Relationship between sol fraction (S) and irradiation dose (R);Influential factor;Molecular attraction;Flexibility of main chain;Molecular weight of polymer;Side group;Filler and filler quantity
摘要:We made an primary investigation on the plasma copolymerization of hexafluoropropene, ethylene and styrene. Through measurement of IR and GC-MS we concluded that although electron energy of the plasma system was high enough to break common chemical bond, the plasma copolymerization just as usual radical copolymerization must follow that the activity of copolymerized monomers need approach each other, or else the high active monomer would polymerize to anticipate copolymerization.
摘要:In order to find more effective radioprotector, a new radioprotectors 3,4,5-trimethoxyphenylpropenoic Acid Diethylaminoethylthiol Ester has been synthesized which is a derivative of Sinapic Acid Thioester by changing known structure of radioprotector Sinapine. The main step to synthesize this agent is involved the condensation of 3,4,5-trimethoxyphenylpropenoic Acid Chloride with diethylaminoethylthiol under base catalyst. And the ESR Spectra from Sinapic Acid Thioester derivative-dTMP and DNA with molar ratio 1:10 irradiated and recorded at 77 K and after annealing at room temperature has confirmed the long range electron transfer from Thymine moiety of dTMP to protector Thioester:The ESR Spectra of Thioester-dTMP and Thioester-DNA binary systems reveal characteristics similar to that from Thioester which represent carboxylic anion radical alone. After annealing at room temperature, the ESR pattern of Thioester-dTMP binary system changed into carboxylic anion of Thioester radical alone, and no traces of ESR signal from 5-thymyl radical could be found. The new synthetic Sinapic Acid Thioester Derivative is one of new kind radioprotectors with "potential thiol" group that is different from literature known radioprotectors such as thiosulfates, phosphorothioates and thio acetic acids from them free thiols may be formed metabolically, and it is estimated to be with lower toxicity and higher protective and therapeutic effect for this new kind agent; The primary antiradiation test on mice irradiated with 60Co γ radiation of 7.5 Gy showed the protective and therapeutic effects by enhancing an mal survival rate of 20% and 40% respectively within 30 days after irradiaradiation in the cases of protective and therapeutic administration of drug with dose of 1.5 mg/mouse (intraperitoneal injection) by comparison with the control group of mice. The Sinapic Acid Thioester Derivative is not only with the activity of radioprotection but also with the activity of reinforcement of injured organism repair processes. So far as described as above, it may be concluded that Sinapic Acid Thioester Derivatives act not only as antioxydants and radical scavengers but also act as affecting repair processes for the injured organism.The Ms. I. R. and NMR Spectra of Sinapic Acid Thioester Devivative also have been reported.
关键词:Radioprotector;Synthesis of Sinapic Acid Thioester Derivative;Charge transfer protection;ESR;DNA;dTMP;Reinforcement of Repair Process for Radiation Injury
摘要:Radiation curing is a branch of radiation processing. It has developed significantly and increased over 10% annual growth rate in the nineteeneighties. Several products were manufactured by radiation curing, such as magnetic media, release coating, floor tile, printing flates, optical fiber, electronics, lithography and pressure sensitive adhesives etc. The chemistry of radiation curing is often considered ahead. The safe handling of UV/EB curable material, the regulation of industrial and the patent protec tion for development in radiation curing were introduced. The equipment and processes of this field have got progress recently.
摘要:Bimolane (AT1727, MST-01) and Prolimane (AT2153, MST-02) belong to diketopepirazine compounds and have some radiosensitizing effect. Are they mutagenic? No mutagenicity of these two compounds have been tested with SOS chromotest. The same results were obtained in all conditions (i. e. different concentration: bacterial strains PQ37 as well as PQ35: with or without activator—S9 mixture). It is coincidence with Ren's report: No mutagenicity in Ame's test, DNA damage induction and sister chromatid exchange has been tested.No cytotoxicity was studied by inductest.
摘要:Sodium chloride is a common additive of food such as salt meat, ham, sausage. Pulse radiolysis experiments [1,2] have shown that ion is detected when concentrated neutral chloride solutions are irradiated. is an active species, it is necessary to pay one's attention to the effect of NaCl in the irradiated food. In. this paper radiation chemistry of stearic acid-NaCl-H2O and oleic acid-NaCl-H2O model systems have been developed by 36Cl radioactive tracer method and Cl- ion selective electrode method. Both methods verify the existence of organic chloride compounds in the system irradiated under 60Co γ -ray.