最新刊期
      期 2 ， 2004
      • LIU Qingjie,FENG Jiangbin,LU Xue
        Vol. 22, Issue 2, Pages: 65-68(2004)
        摘要：Mitochondrial DNA (mtDNA) is the only genome outside cell nucleus. It is very sensitive to oxidative damages, such as radiation, because of absence of histone protection and lacking efficient DNA repair mechanism. The paper summarizes research progresses on mtDNA in the field of radiosensitivity, radiation dose-effect relationship, radiation-induced mutation and carcinogenesis in recent years. Prospective application of mtDNA in radiation biology is also outlined.  
        关键词：Mitochondrial DNA;Radiation biology;Application   
        2
        |
        0
        |
        0
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 35824901 false
        发布时间：2023-03-30
      • CHEN Lai,CHEN Jie,WANG Yahua,LIU Yinfeng,LI Jianjun,ZHANG Jiabao
        Vol. 22, Issue 2, Pages: 73-76(2004)
        摘要：Polypropylene amidoxime (PPAO) chelate fibre is synthesized by pre-irradiation graft polymerization and amidoximation. Influences of irradiation atmosphere, type of solvent, solution volume and monomer concentration on degree of grafting were studied. Experimental results show that higher degree of grafting could be achieved by irradiating the PPAO finres in air at 70ºC and grafting the samples in a monomer solution of 30% acrylonitrile in concentration solved in water or 10% methol aqueous solution. Adsorption of Pb(Ⅱ) by the grafted PPAO was tested, and Pb(Ⅱ) adsorption capacity of 0. 362 mg per gram of the fibre (dry weight) could be obtained.  
        关键词：Preirradiation grafting;Amidoxime chelate fibre;Polypropylene fiber;Pb(Ⅱ) ion adsorption   
        3
        |
        0
        |
        5
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 35824854 false
        发布时间：2023-03-30
      • SUI Gang,LIANG Ji,ZHANG Zuoguang,LI Dan,CHEN Huijuan
        Vol. 22, Issue 2, Pages: 77-81(2004)
        摘要：The influences of molecular weight on electron beam (EB) curing in epoxy resins were studied. The rate of radiation reaction in epoxy resin systems decreases with the increasing molecular weight. Under the low radiation dose, the curing thickness and curing degree is small for samples with high molecular weight. The effect of molecular weight decreases with the increasing radiation dose. The glass transition temperature (Tg) and the storage modulus (E＇) are under the control of curing degree in samples, and the molecular weight will play a role on the samples with similar curing degree. After heat treatment, the Tg and E＇of epoxy resins cured by radiation will increase. The molecular weight is directly associated with effect of heat treatment.  
        关键词：Epoxy resin;Electron beam;Radiation curing;Molecular weight;Curing degree   
        2
        |
        0
        |
        0
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 35824855 false
        发布时间：2023-03-30
      • RUAN Weiqing,QIAO Jinliang,LIN Jichen,HUANG Yuli,NIU Aijie
        Vol. 22, Issue 2, Pages: 82-86(2004)
        摘要：Synthesis of acrylic acid-acrylate salt (acrylic acid-potassium acrylate and acrylic acid-sodium acrylate) copolymer super absorbent resin (SAR) by UV photopolymerization have many merits compared with traditional methods, such as simple technology, short reaction time, normal temperature operation and no pollution. Photoinitiator is the most important factor of photopolymerization. In this paper, several kinds of photoinitiators ( Iragure651、Iragure819、Iragure184、Iragure1700、Iragure1800 and Iragure2929) were studied, including the influence of varieties and concentration on the performance of UV copolymerization and the water absorption capacity of SAR. It shows Iragure651, Iragure1700 are efficient photoinitiators for photopolymerization of SAR. The proper exposing time for preparing SAR was about 10min. Using Iragure651 as photoinitiator, the water absorbency and 0.9% NaCl absorbency of acrylic acid-potassium acrylate copolymer SAR reach 1358mL/g and 115mL/g respectively.  
        关键词：UV photopolymerization;Photoinitiators;Super absorbent resin   
        3
        |
        0
        |
        9
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 35824903 false
        发布时间：2023-03-30
      • JIAN Le,YAO Side,QIAN Suping,JIN Zhongchu
        Vol. 22, Issue 2, Pages: 87-91(2004)
        摘要：Laser flash photolysis technique was used to study photo-chemical mechanism of CS2 under the excitation of 308nm laser and determine related rate constant involved in excitation of carbon disulfide (CS2). The laser flash photolysis showed that the excited triplet of CS2 could be quenched by its ground state to generate CS2 free radical intermediates. Meanwhile, rate constant for the quenching was also obtained. The radical cation and anion of CS2 produced in laser flash photolysis were further confirmed by pulse radiolysis with their characteristically transient absorption. Results presented in this paper may support the direct evidence for the hypothesis of CS2 oxidative injury to biologic tissue.  
        关键词：Carbon disulfide;Laser flash photolysis;Pulse radiolysis   
        2
        |
        0
        |
        1
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 35824912 false
        发布时间：2023-03-30
      • WANG Min,YANG Ruiyuan,WANG Wenfeng,BIAN Shaowei,SHEN Zhongqun
        Vol. 22, Issue 2, Pages: 92-96(2004)
        摘要：The textile industry has been recognized as one of the largest pollution sources of wastewater in China. In this study, the possibility of using irradiation technology to degrade reactive dye in aqueous solution was investigated. The reactive blue KNR in aqueous solutions under different conditions were irradiated by 60Co γ-rays to 4.3, 8.9, 13.7, 17.4 and 20.3 kGy, respectively. Changes of absorption spectra, chemical oxygen demand (COD) and degree of decoloration were examined. A COD removal efficiency of 80% and a decoloration rate of 100% could be obtained. The results suggests that te irradiation technology shall be a promising process for treatment of textile dye waste effluents.  
        关键词：Irradiation;Reactive blue KNR;Degradation;Decoloration;Chemical oxygen demand (COD)   
        3
        |
        1
        |
        12
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 35824909 false
        发布时间：2023-03-30
      • TANG Ganghua,WANG Mingfang,TANG Xiaolan,WU Hubing,HUANG Zuhan
        Vol. 22, Issue 2, Pages: 97-100(2004)
        摘要：Based on mice biodistribution data, absorbed doses in humans due to intravenous administration of 13N-NH3•H2O can be estimated, so as to evaluate the safety of PET diagnosis with 13N-NH3•H2O in humans. 13N-NH3•H2O was injected into mice through a tail vein. At 0, 0.5, 1, 2, 5, 10, 20 and 30 min after the injection, the mice were killed by cervical fracture and biodistribution in mice was determined. Radiation dosimetry in humans was calculated on the base of organ distribution in mice and the standard MIRD method using radioactivity-time curves for humans. The liver in humans received the highest dose of 3.6×10-3 mGy/MBq. The whole body received the lowest dose of 1.7×10-3 mGy/MBq, and other organs received doses between 2.4 ×10-3 and 3.3 ×10-3 mGy/MBq. The effective dose was estimated to be 1.8×10-3 mSv/MBq. These results were comparable to values of absorbed doses reported by other authors on radiation dosimetry of this radiopharmaceutacal. Human radiation dosimetry can be performed by the mice biodistribution data and important data for clinical safe trial of 13N-NH3•H2O are provided.  
        关键词：13N-NH3•H2O;Mice;In vivo biodistribution;Radiation absorbed doses   
        2
        |
        0
        |
        2
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 35824982 false
        发布时间：2023-03-30
      • LI Shangzhi,LIU Qingfang,CHENG Haixia,ZHANG Tongcheng,WANG Chunlei,JIANG Jianping
        Vol. 22, Issue 2, Pages: 101-105(2004)
        摘要：Based on ISO11137 , bioburden of 3M Steri-DrapeTM and the sterilization dose were determined. Results indicted that the adjusted average bioburden was 3082.5cfu per device, verification dose was 12.6kGy and the minimum sterilization dose was 26.8kGy (SAL 10-6). The irradiated sample products were tested to verify properties of the package materials and biocompatibility of the device. Results showed that after the irradiation and accelerated aging test, the sample products and the package were qualified. The device remained sterile and no adverse response was found in cytotoxicity test, animal test and clinical applications.  
        关键词：3M Steri-DrapeTM;Radiation sterilization;SAL;Bioburden   
        2
        |
        0
        |
        0
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 35825014 false
        发布时间：2023-03-30
      • NI Meinan,ZHAO Kui,SUI Li,MEI Junping,GUO Jiyu,WANG Ruyu
        Vol. 22, Issue 2, Pages: 106-110(2004)
        摘要：DNA , the carrier of bio-information, is the most important target molecule in radiobiology. In order to understand the DSB mechanism of DNA molecules induced by ionizing radiations, the structure and property of DNA molecule and its DSB fragment shall be studied. In this paper, three kinds of purified DNA molecules were observed by Tapping Mode AFM in atmosphere. One kind of the DNA molecules in water solution was irradiated by 241Am-α source irradiation device. Intuitive images of the molecules and DSB fragments were obtained. By this way, further study of statistic model of probability of the DSB of DNA molecules induced by various radiations, especially heavy ions, could be carried out.  
        关键词：DNA;AFM;Bio-sample Adsorption;AFM Tip Broadening Effect;Double Strand Breaks   
        2
        |
        0
        |
        1
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 35824984 false
        发布时间：2023-03-30
      • LIU Fenju,SUN Cuifeng,CHEN Jian,NING Ping
        Vol. 22, Issue 2, Pages: 111-113(2004)
        摘要：The results indicate that in 2—10Gy range of the γ-ray irradiation, a linear relations (r=0.881) were found between the irradiation dose and DNA concentration,. When the number of cells was 8×107—10×107, the concentration of DNA cells related linearly, too, with relative fluorometric intensity. Difference in concentrations of the LexA protein showed no significant protection on DNA strand breaks caused by the γ-rays.  
        关键词：FADU;LexA;DNA strand breaks;60Coγ-rays   
        2
        |
        0
        |
        0
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 35824981 false
        发布时间：2023-03-30
      • LIU Yongbiao,LIU Ying,ZHAO Jie,HAO Xingzhi,WANG Xu,YAO Side
        Vol. 22, Issue 2, Pages: 114-122(2004)
        摘要：By determination of ROS and apoptosis of Hela cells in mice at different hours after treatment with DDP, ADM or VP-16, the relations between apoptosis of Hela cell induced by chemotherapic Drug and concentration of ROS has been investigated. It has been found that there is no effect on apoptosis, and the P53 and c-fos expressions, of the Hela cells when SOD was applied 24 hours after the chemotherapy, whereas apoptosis of the Hela cells reduced when SOD was applied beforethe chemotherapy. Comparing with the control group, to which just ADM and DDP were given, ROS levels reduced markedly in bone marrow, liver and spleen of the tumor-bearing mice, which had been treated with SOD for five consecutive days 4 hours after the chemotherapy. It can be inferred that the oxidation damage of normal tissue can be avoided with scavenge of excessive ROS and increase of anti-oxidative enzymes by SOD in the chemotherapy. The results suggest that injecting SOD at suitable time in clinic chemotherapy may be useful for reducing the side effects.  
        关键词：Superoxide dismutase;Chemotherapic medicine;Apoptosis of tumor cell;Hela cell   
        2
        |
        0
        |
        0
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 35824986 false
        发布时间：2023-03-30
      • WANG Xiaomei,JU Guizhi,MEI Shujiang,FU Shibo,LIU Shuzheng
        Vol. 22, Issue 2, Pages: 123-125(2004)
        摘要：To investigate the effect of ionizing radiation on p16 gene transcription and protein expression in EL-4 cells in vitro, RT-PCR semi-quantity method was applied to determine the p16mRNA level and immunocytochemistry (ICC) was employed to measure the p16 protein expression. The time-course experiments showed that the p16 mRNA level increased at 2—48h in EL-4 cells, and the p16 protein expression increased significantly in EL-4 cells (p<0.01) at 12h after 2.0Gy X-irradiation. The dose-effect experiments showed that the p16mRNA level increased with the dose, and the p16 protein expression increased significantly (p<0.01) with the dose in 2.0 - 6.0Gy range. The results suggested that the increase of p16 gene transcription and protein expression in EL-4 cells might play role in G1 arrest induced by ionizing radiation in vitro.  
        关键词：X-rays;G1 arrest;p16 protein;p16 mRNA   
        2
        |
        0
        |
        0
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 35825028 false
        发布时间：2023-03-30
      • MA Shumei,LIU Xiaodong,GONG Pingsheng,MU Ying,YAN Ganglin,LUO Guimin
        Vol. 22, Issue 2, Pages: 126-128(2004)
        摘要：The work was to study protective effect of 2-selenium Bridged β-cyclodextrin (2-Se-CD), a GPX mimic, on the damages induced by moderate-wave ultraviolet rays. UVB damage model was established with murine fibroblast, NIH3T3. DAPI and MDA were used to evaluate DNA lysis rate and lipid peroxidation level respectively, Flow cytometry was used to detect production of H2O2. Significant increases were found in the DNA lysis rate, the lipid peroxidation level and the H2O2 production 24 h after the treatment of 1.5 kJ m-2 UVB. However, adding 2-Se-CD to the sample solutions could reduce all the changes to different extent. The DNA lysis rate, lipid peroxidation level and the H2O2 production decreased as compared with the damage model group (p<0.05—0.01). The results suggested that 2-Se-CD might protect NIH3T3 from the damage induced by moderate-wave ultraviolet rays,  
        关键词：2-Se-CD;UVB;protective effect   
        2
        |
        0
        |
        0
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 35825027 false
        发布时间：2023-03-30

        研究论文

      • XIN Lihui,ZHOU Ruimin,Ekoko Bakambo Gracien,Adeleke O. Francis
        Vol. 22, Issue 2, Pages: 69-72(2004)
        摘要：A new electron beam method has been successfully developed to prepare silver nano-particles at room temperature and ambient pressure, without any kind of catalysts. The structure, morphology, size, optical properties and the melting point have been characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), ultraviolet-visible spectrophotometer (UV-vis) and differential scanning calorimeter (DSC) were utilized to characterize the product. TEM results show that the average size of silver nano-particles is about 30nm in agreement with the calculated value size from XRD using Scherer formula.  
        关键词：silver nano-particle;electron beam;radiation;electron accelerator   
        3
        |
        0
        |
        3
        <HTML>
        <L-PDF><Meta-XML>
        <引用本文> <批量引用> 35824851 false
        发布时间：2023-03-30
      0