最新刊期
      期 2 ， 1995
      • Luo Liming,Zheng Rongliang,Lin Nianyun,Jin Yizun
        Vol. 13, Issue 2, Pages: 65-68(1995)
        摘要：Sister chromatid exchange (SCE) and inhibition of cell proliferation ratio index (PRI) in human lymphocytes were induced by ionizing irradiation, superoxide anions and hydroxyl radical. There was a negative relationship between SCE and PRI. It was suggested that those biological effects were caused by superoxide anions and hydroxyl radicals produced in irradiated cells.  
        关键词：Ionizing irradiation;Hydroxyl radical;Superoxide anion;Sister chromatid exchange;Cell proliferation ratio index   
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        发布时间：2023-05-04
      • Fan Feiyue,Gong Yifen,Wu Dechang,Liu Guolian
        Vol. 13, Issue 2, Pages: 74-78(1995)
        摘要：The α-particles effects on the functions of phagocytosis and receptor Fc of macrophage were studied, in which α-irradiation was emitted from 238Pu source and macrophage like cell line P 388 D1 were tested. Difference of sensitivities between phagocytosis and receptor Fc to α-irradiation was analysed. The changes differed with different durations of post-irradiation and doses of α-irradiation. Phagocytic function was enhanced during early period of post-radiation by low dose irradiation. Phagocytic function decreased certainly under large doses and/or long duration of post-irradiation. Relationship between doses and effects on suppression of phagocytosis was definite, which was a model of single decrease and suited to formula of minus exponent. Trend of suppressive changes both phagocytosis and receptor Fc was compared. The result indicated that the decrease of phagocytosis with increase of doses was faster than that of receptor Fc. It was suggested that phagocytosis was more sensitive to α-irradiation than function of receptor Fc.  
        关键词：α-irradiation;Phagocyte;Immunology   
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        发布时间：2023-05-04
      • Gao Qingxiang,Wang Yong,Yang Hanmin,Jiang Xinliu,Shong Zhimin
        Vol. 13, Issue 2, Pages: 79-83(1995)
        摘要：In this report, free radical yields in plant seeds (tomato, wheat, hot pepper and cucumber) irradiated by intense pulsed electron beam and ion beam were proved to be in positive proportion with doses. But the ability of seed germination is approximately in negative proportion with the free radical yield. Chromosomal aberrant frequency is approximately in positive proportion with the free radical yield in seeds. The results showed that the effectiveness of pulsed electron beam is stronger than that of pulsed ion beam. This methed proved to be simple and effective for using intense nanosecond pulsed electron beam and ion beam radiation to induce mutant in plant.  
        关键词：Free radical;Electron beam;Ion beam;1rradiation effect;Tomato;Wheat;Hot pepper;Cucumber   
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        发布时间：2023-05-04
      • Zhang Chunxiang
        Vol. 13, Issue 2, Pages: 84-90(1995)
        摘要：The calculation of the cross-sections for the inactivation of enzymes and viruses has been made, assuming these to be 1-hit detectors. The calculation makes use of a power-law empirical formula for the radial distribution of dose about the path of an energetic heavy ion. The calculation is made by assuming that the probability of inactivatinga molecular target by irradiation with a given dose of delta rays is equal to the probability of inactivating it with the same dose of gamma-rays. The cross-section is found by adjusting the assumed value of the D37 dose of gamma-rays until an optimal fit of the calculation to the measured cross-sections is obtained. Taking all 72 cross-section measurements into account, the average ratio of experimental to calculated cross-sections is 0.96±0.11, while the average ratio of the experimental to the fitted value of the gamma-ray D37 dose is 1.07±0.18.  
        关键词：Heavy ion;Dose distribution;Inactivation cross-section;Viruses;Enzymes   
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        发布时间：2023-05-04
      • Wang Tao,Wang Hongyun,Zhang Junning
        Vol. 13, Issue 2, Pages: 91-94(1995)
        摘要：It was shown that colony stimulating factor (CSF) extracted from human urine could increase survival rate obviously and prolonged survival time in irradiated mice. Using tissue culture mini-well plate by means of limiting dilution method, it was shown that with CSF the mature granulocytes in peripheral blood could be kept survival and the counts of them were closely correlated with the concentrations of CSF. With CSF (200 u/ml), in the bone marrow culture the numbers of granulocyte-macrophage colony forming unit (CFU-GM) at the 12th day were larger than that at the 8th day.  
        关键词：Colony stimulating factor(CSF);Survival cells;Granulocyte-macrophage colony forming unit (CFU-GM);Haemopoietic function   
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        发布时间：2023-05-04
      • Ju Guizhi,Shong Chunhua,Qi jin,Liu Shuzheng
        Vol. 13, Issue 2, Pages: 95-98(1995)
        摘要：In the present study the range of preirradiated doses (D1) and challenge doses (D2) for the induction of immunological adaptive response and the optimum time intervals between D1 and D2 were investigated in Kunming mice. The results were as follows. 1. Single whole body preirradiation by X-rays with D1 doses of 25~100 mGy (12.5 mGy/min) could induce adaptive response of spontaneous incorporation of 3H-TdR into thymocytes and the reaction of splenocytes to LPS. 2. With D2 doses of 1.0 to 1.5 Gy, the adaptive response of spontaneous incorporation of 3H-TdR into thymocytes and the reaction of splenocytes to ConA and LPS could be induced. 3. The optimum interval for the induction of immunological adaptive response be tween D1 and D2 could be 6~12 h.  
        关键词：Low level radiation;Immunological adaptive response;Thymocytes;Splenocytes   
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        发布时间：2023-05-04
      • Xie Hongmei,Wei Zengquan,Li Wenjian,Yang Weicheng,Wang Li,Feng Jietian,Tian Weijin
        Vol. 13, Issue 2, Pages: 99-101(1995)
        摘要：The mutation induction effects of deep red micromonospora (one of QDMS reproductive Actinomyces) implanted by energetic ions (7 MeV/u O6+) were determined and analysed in the paper. Mutation of strains induced by heavy ions and morphological changes of strains in separate process were observed. Efficient value increased by 30% and positive mutation rate was as high as 27.5% by way of breeding.  
        关键词：QDMS;Mutation induction of microbe;Energetic heavy ion;Deep red micromonospora;Ion implantation   
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        发布时间：2023-05-04
      • Wang Tiandiao
        Vol. 13, Issue 2, Pages: 102-104(1995)
        摘要：The radiation-induced colour change of tourmaline from Altay in Xingjang wad studied by heat treatment, X-ray diffraction, X-ray flouorescence spectrometry, absorption spectrometry. It was shown that the colour change effect conditioned by the change of 19500 cm-1 and 13800 cm-1 spectra ascribed to d-d transition of Mn3+ and Fe2+ in b site.  
        关键词：Radiation;Colour change;Tourmaline;Heat treatment   
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        发布时间：2023-05-04
      • Du Zeji,Su Liaoyuan,Tian Hailin
        Vol. 13, Issue 2, Pages: 105-108(1995)
        摘要：Human peripheral blood lymphocytes PHA-stimulated in vitro for 24 h were exposed to low dose γ-ray irradiation (adaptive dose), they showed an adaptive response to the inhibition of DNA synthesis by subsequent higher acute doses of γ-ray (challenge dose). At the interval of 24h between adaptive dose and challenge dose, the most obvious adaptive response induced by low dose irradiation was found. It was also found that the response induced by 1.0 cGy of adaptive dose was more obvious than that by other doses. In the challenge doses range of 1.0~7.0 Gy, the adaptive response was observed and that 3.0 Gy was more obvious. The adaptive response disappeared with the challenge doses further increased.  
        关键词：Low dose irradiation;Lymphocytes;DNA synthesis   
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        发布时间：2023-05-04
      • Yang Liling,Gao Jinsheng,Zheng Siying
        Vol. 13, Issue 2, Pages: 109-113(1995)
        摘要：Chromosome aberrations induced by various 60Co γ-ray doses(0~3 Gy) were examined in secondary oocytes and bone marrow cells of ICR mice. The chromosome aberration rates of the two cell lines were both significantly higher in γ-irradiated groups than that in control ones. Using four models recommended by WHO, dose-response calibration curves were established and better matches were selected: they were , for aberrant cell and total chromosome aberration rates(%) of oocytes, respectively. And , for aberrant cell and total chromosome aberration rates(%) of bone marrow cells, respectively. A comparison of radiosensitivity between MⅡ oocytes and bone marrow cells were also made, the results showed that both MⅡ oocytes and bone marrow cells were sensitive, the bone marrow cell radiosensitivity was higher than that of MⅡ oocytes by 2.2 times.  
        关键词：60Co γ-ray;Chromosome aberration;Dose-reaponse relationship;Radiosensitivity   
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        发布时间：2023-05-04
      • Xie Huaijiang,Song Juzhong,Peng Tao,Jin Huanrong
        Vol. 13, Issue 2, Pages: 114-117(1995)
        摘要：This paper reports the research results which the slow release anticancer drug 1 - (2-tetrahydrofuryl-5-fluorouracil) (FT-207) was made by radiation induced polymerization of monomers such as methacrylates with FT-207 at room temperature. The differences of UV and IR spectrum between drugs irradiated and non-irradiated were not obvious when samples were irradiated with doses less than 16.25 kGy at room temperature. In vitro the rates of drug release were remained stable a few days after administration. In vivo the therapeutic effect was obvious on sarcoma S180 and Lewis lung cancer in mice when the preparations were embedded hypodermally near the tumor.  
        关键词：Radiation polymerization;Immobilization;FT-207;Methacrylates;Drug delayed release   
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        发布时间：2023-05-04
      • Jiang Tienan,B. I. Lord,J. H. Hendry
        Vol. 13, Issue 2, Pages: 118-122(1995)
        摘要：The radial distribution of CFU-S in the femur of a normal 8 weeks old mouse is shown and corresponds closely to Lord and Hendry. The highest concentration (about 41/105 cells) was near to the bone surface and the lowest (about 22/105 cells)was close to the central venous sinus which runs roughly along the longitudinal axis of the bone shaft. Continuous exposure to γ-rays for 6 d from 13d of gestation to birth had a smaller effect on the total femoral cellularity at 8 weeks of age, decreasing it by 12%~20%. The 15 cGy/d regimen caused a significant(20%) CFU-S deficit (p<0.02) in the marginal zones. The 60 cGy/d schedule increased the deficit to a level (33%) and the change in the femoral CFU-S distribution after γ-ray irradiation is also shown. The 60 cGy/d schedule also reduced the fibroblastoid, CFU-F population, to 67% of control (P<0.001). The 15 cGy/d reduced to 88% of control.  
        关键词：Pregnant mice;Offspring of mice;γ-irradiation   
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        发布时间：2023-05-04
      • Liu Yuanzhao,Gou Ying,Liu Mingyuan
        Vol. 13, Issue 2, Pages: 123-125(1995)
        摘要：A Lymphomas case was treated with whole body irradiation. The results showed that micronucleated cell frequency and micronucleus frequency were very similar between the blood samples irradiated in vitro and in vivo. The differences were not singnificant (p>0.5). The patterns of the curves obtained from regression analysis were identical, and the differences among the two regression equations of the same parameter were not singnificant, it is considered that dose effect was almost the same between the blood samples irradiated in vitro and in vivo in certain dose extent. The micronucleus frequency of human peripheral blood lymphocytes could be applied as a supplementary criterion fordose estimation to irradiated human at early stage of nuclear accident.  
        关键词：Micronucleus frequency;Irradiation in vitro;Irradiation in vivo;Lymphocyte   
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        发布时间：2023-05-04
      • Su Xu,Zhang Yingchun,Liu Shuzheng
        Vol. 13, Issue 2, Pages: 126-128(1995)
        摘要：Programmed cell death(PCD), or apoptosis, is a conceptually different way of cell death from necrosis. PCD plays an important role in immunologic regulation. PCD in thymocytes was analyzed by flow cytometry following in vitro X-irradiation. It was found that culturing of thymocytes could induce PCD which showed a time dependent increase. Four hours after culturing, 16% of thymocytes was found in the Ao region (PCD is shown in the Ao region of the histogram of flow cytometry). PCD in thymocytes showed a time dependent increase after 2.0 Gy X-irradiation, being significantly higher than that in the control at the same culturing time. 24 hours after X-irradiation in vitro, it was found that with 'doses below 100 mGy PCD was not significantly differrent from the control at the same culturing time. but when the doses were above 100 mGy, PCD showed a dose dependent increase, being significantly higher than that of the control at the same culturing time. These results are important in the understanding of the biological effects of low dose radiation.  
        关键词：Programmed cell death (PCD);Flow cytometry (FCM);Thymocytes;X-rays   
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        发布时间：2023-05-04

        研究论文

      • Wu Jilan,Ha Hongfei,Zhang Xujia
        Vol. 13, Issue 2, Pages: 69-73(1995)
        摘要：This paper reviewed the progress of research on biomedical products and synthesis of biomaterials by radiation technology. The promising prospect and some proposals have been discussed as well.  
        关键词：γ-sterilization;Synthesis of biomaterials;Immobilization;Hydrogel;Radiation processing   
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        发布时间：2023-05-04
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